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Anabolic steroids are synthetic substances, derived from the male hormone testosterone, that increase muscle size and strength. Many of these drugs can have dangerous side effects, including cancer and death. These drugs, often called “performance-enhancing” because of their positive effects on performance, are banned in the United States, and in many sports federations around the world, buy steroids from overseas.
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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.1 mg/kg/h. A small (4.5% vs. 32.5%) risk per additional dose for the first dose was observed, so it should be considered that a single prednisolone dose of 1 mg/kg/h and no increase in dose might lead to a similar increase in risk. A larger study involving 5,000 patients would be needed to confirm this risk. Another significant finding was that the mean age at onset of treatment for patients with severe TBI was significantly lower than the median (25 vs. 34 years; P<0.01). The mean age of onset is a crucial marker to assess the disease's progression and its impact on outcome. The use of steroids in patients with severe TBI should not be ruled out. This paper was based on a 3-week, multicenter, randomized, open-label, acute-phase study involving 50,500 patients. Patients receiving steroid medication were treated with one of four corticosteroids (prednisolone, prednisolone with codeine, prednisolone with hydrocodone, or placebo) or with an inert placebo. The efficacy, safety, and tolerability of therapy were evaluated in a prospective crossover study including patients with different severity of TBI. Overall, there was a statistically significant overall improvement in the quality of life and overall functioning as measured on a composite score at 1-, 2-, 3-, and 4 wk from the original injury. However, this difference was not significant between the groups. "Prednisolone and prednisolone with hydrocodone in the treatment of traumatic brain injury in adults with traumatic brain injury: A prospective, open-label, acute-phase study," is published online in the Journal of Traumatic Stress.
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