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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal painin post-menopausal women.
Methods
English-language articles were selected and their abstracts abstracted. A structured search was started by using PubMed (1966 – July 2009). There was a total of 17,717 abstracts retrieved and they were screened by two independent researchers (J.B.F. and K.J.T.). Abstracts were examined for important differences or important limitations, including the presence of clinical trials, type of analgesic, and effect on disability.
Data extraction and analysis
The results of the initial search and screening were then used. All studies with relevant results were summarized using descriptive statistics, including the following:
Study characteristics: mean age, proportion of women presenting with musculoskeletal pain, and sex, and whether or not the study was a randomized controlled trial and, if it was, the size of the study (number of patients involved), design (randomized, non-randomized, observational design, etc), duration of intervention compared to the placebo group, intervention period, use of a corticosteroid on the first treatment day, duration of follow-up, and the outcome measures.
Comparison of effectiveness of corticosteroid injected vs. non- injected controls: the rate of adverse events (AEs) during treatment, the number needed to treat (NNT) for adverse events on days three and six and for number needed to treat on day four and 10, and how often the group receiving the corticosteroid was pain-free on the first day of the treatment period; as well as the effect duration of the study (days two through six).
Effect of duration of treatment: duration of the treatment, the number needed to treat (NNT) from days two through six and from day 10 of the treatment period, number of patients at baseline, and a measure of how often the group was pain-free during the treatment period, and effects on the secondary outcomes of the study.
Effect on the secondary outcomes: number of deaths, all adverse reactions, and how many patients were required to take a drug like acetaminophen to prevent the AE.
The methods for using the data were described in detail elsewhere.14 There were seven articles selected from the original 17,717 identified; data were extracted and examined for quality and quality adjustment.
Results
The analysis of the data
The summary of findings of this systematic review was very similar to most systematic reviews on the topic.
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